RePHILL

Full title: Resuscitation with Pre-Hospital Blood Products

Aim: this trial investigates whether giving blood products (red blood cells and freeze-dried plasma) to badly injured adult patients before reaching hospital improves their clinical condition.

Background: This trial investigates whether giving blood products (red blood cells and freeze-dried plasma) to badly injured adult patients before reaching hospital improves their clinical condition.

The best treatment for injured patients with major bleeding before reaching hospital is uncertain; patients are usually given clear fluids (salt solution) through a drip and may receive blood products after arriving in hospital. Some research suggests that giving blood products before the patient reaches the hospital may improve clinical outcomes. This has not been proven.

This trial is being carried out across regional trauma networks in England. Injured patients with major bleeding are divided randomly into two groups. Both groups are treated by pre-hospital emergency teams (with both doctors and paramedics) at the scene and during transport to hospital.

One group receives the “standard treatment” – small volumes of clear fluid.

The other group receives blood products (small volumes of red blood cells and freeze dried plasma)