Androgen precursor Dehydroepiandrosterone Pharmacokinetics in Trauma (ADaPT)

Lead researchers: Mr Conor Bentley, Ms Katie Young, Mrs Niharika Arora, Prof W Arlt, Prof Janet Lord, Lt Col Mark Foster

Aim: To find the correct dose to help restore the normal levels of Dehydroepiandrosterone (DHEA) in trauma patients and study the balance between DHEA and Dehydroepiandrosterone  Sulphate (DHEAS) just after trauma occurs when the imbalance is at its maximum.

Background:

Improvements in the short-term outcomes after severe trauma achieved through early resuscitation may be off set in the medium term by acute inflammatory responses, leading to infection. This excess pro and anti-inflammatory environment in the body impairs the period of rehabilitation that the patient will be undergoing. Research from the SIRS Study (insert link) has shown that a major circulating steroid precursor of sex hormones, Dehydroepiandrosterone (DHEA ) and its stored form DHEAS are low immediately after injury.

Method:

Patients who have undergone a trauma will be identified by members of the research team at the SRMRC.  After seven days in intensive care, patients will have their usual levels of DHEA and DHEAS measured in the blood. On day eight the patient will be randomly assigned to either receive a DHEA supplement to be placed under their tongue or to be swallowed. If the patient stays in hospital, they will consume the DHEA supplement for two more days to see if it has any beneficial effect upon the cells responsible for the immune response after injury.

This data will then be used to develop and design a much larger randomised controlled trial in trauma patients.

Measure findings: By measuring the levels of DHEA and DHEAS in the blood after supplementation with either a sublingual or oral dose of 50mg.  

Lead researchers

  • Androgen precursor Dehydroepiandrosterone Pharmacokinetics in Trauma  (ADaPT)

    Conor Bentley

    Mark Foster's team

    Conor Bentley
  • Androgen precursor Dehydroepiandrosterone Pharmacokinetics in Trauma  (ADaPT)

    Lieutenant Colonel Mark Foster

    Mark Foster's team

    Maj Foster is a research fellow for the Academic Department of Military Surgery and Trauma and the NIHR SRMRC. He is in his second year working full-time towards his PhD but also does clinical work on hand trauma.

    Lieutenant Colonel Mark Foster
  • Androgen precursor Dehydroepiandrosterone Pharmacokinetics in Trauma  (ADaPT)

    Professor Janet Lord

    Janet Lord's team / Principal/Chief Investigator

    Prof Lord is director of the University of Birmingham’s Centre for Healthy Ageing Research and is also head of the University’s Centre for Translational Inflammation Research, which is located within the new Queen Elizabeth Hospital Birmingham and due to open in the summer of 2011.

    Professor Janet Lord