Trauma research quarterly newsletter – Q3, 2013
14 October 2013
Ocular team publishes on blunt trauma
SRMRC’s ocular trauma researchers have produced their first published paper, looking at visual outcomes after blunt trauma.
The paper was published in the August issue of Ophthalmology, the official organ of the American Academy of Ophthalmology.
The paper describes the prognosis and retinal location in patients presenting with acute traumatic maculopathy and extramacular retinal injuries.
SRMRC Clinical Research Fellow Richard Blanch is the lead author for the paper, which was overseen by Prof Rob Scott and included input from Dr Peter Good, Prof Peter Shah, Dr Jon Bishop and Prof Ann Logan.
Research shows value of vinegar
SRMRC microbiologists have played a key role in a publication which shows the efficacy of acetic acid — a major component of vinegar — as an antibacterial agent.
The paper in the Journal of Hospital Infection examines acetic acid’s activity against a range of bacterial pathogens and also assessed its reduction in antibacterial activity due to evaporation or inactivation by organic material in dressings.
Patient and families engagement event
On October 18, SRMRC is holding the first event for its patient and families group.
The event is being held in the Postgraduate Centre at the Queen Elizabeth Hospital Birmingham, and is open to any patient who has taken part in an SRMRC study. Family members are also welcome.
The event is designed to get ideas and feedback about the experience of the patients and their families to inform how SRMRC develops its ideas for both quantitative and qualitative research in the future.
Medical devices event
The NIHR Healthcare Technology Co-operative (NIHR HTC) is hosting a Medical Devices for Wound and Trauma Management event on 29th October.
The event is being held at the Postgraduate Medical Centre at the Queen Elizabeth Hospital Birmingham.
This event focuses on the following clinical areas:
1. Burns management
2. Reducing infection
3. Pain management
4. Interventions to maintain muscle mass
Trials continue to recruit well
Following the successful recent conclusion of the SIRS study, the trials team is continuing to recruit patients at an impressive rate.
SRMRC was the world’s sixth best recruiter to the international SyNAPSe trial of progesterone for use in traumatic brain injury. The trial has now reached its global target
recruitment and is closed to new recruits.
The centre is the UK’s second highest recruiter for HARP-2 and CRASH-3, and third highest for WOLLF.
Latest news on our research themes
Theme 1: Acute Response to Injury
The team, led by Prof Janet Lord and Prof Mark Midwinter, is working with Cranfield Health to develop a new coagulopathy assessment instrument.
Work is also underway on the use of metabolomics to understand the inflammatory response to trauma. Metabolomics is the study of the substances produced by or necessary for a particular metabolic processes in cells, tissues, and organs
Prof Lord and Prof Midwinter have also collaborated on a recently published paper on the use of statins in trauma.
- Click here to view the paper on PubMed
- Click here to visit the Acute Response to Injury theme on the SRMRC website
Theme 2: Microbiology
Three new staff members have started recently. Szymon Calus is working on the various strands DNA sequencing work, while Marc Niebel and Fenella Halstead have joined the team as clinical scientists.
Josh Quick is producing interesting results in the culture-independent diagnosis work package, working out various factors which influence the sensitivity of DNA sequencing.
Theme 3: Reconstructive and Regenerative Medicine
Professor Liam Grover is leading work to create a dressing material which has the ability to reduce or prevent scarring. The dressing will improve the quality of life for people who might otherwise suffer from scarring following an injury.
SRMRC researchers have had success with several publications since the centre’s inception. These
include the following:
- Fraise, AP, Wilkinson MAC, Bradley CR, Oppenheim B, Moiemen N. The antibacterial activity and stability of acetic acid. Journal of Hospital Infection. 2013; 84 (4); 329-331.
- Chan JZ, Halachev MR, Loman NJ, Constantinidou C, Pallen MJ. Defining bacterial species in the genomic era: insights from the genus Acinetobacter. BMC microbiology. 2012;12:302.
- Chan JZ, Pallen MJ, Oppenheim B, Constantinidou C. Genome sequencing in clinical
microbiology. Nature biotechnology. 2012;30(11):1068-71.
- Blanch RJ, Good PA, Shah P, Bishop JR, Logan A, Scott RA. Visual Outcomes after Blunt Ocular Trauma. Ophthalmology. 2013.
- Jansen JO, Lord JM, Thickett DR, Midwinter MJ, McAuley DF, Gao F. Clinical review:
Statins and trauma – a systematic review. Critical care. 2013;17(3):227.
- Penn-Barwell JG, Bennett PM, Fries CA, Kendrew JM, Midwinter MJ, Rickard RF. Severe open tibial fractures in combat trauma: management and preliminary outcomes. The bone & joint journal. 2013;95-B(1):101-5.